Yeast causing infammation

boy's momMember

My son has some increased inflammation shown in his Cal Protectin rate. Other than more fatigue, he has no change in any symptons. He has been on chronic antibiotics for almost two years and humira for 18 months. We spaced out his humira intervals to 4 weeks because he has been doing well but his GI thinks he needs to make reduce the intervals. Another dr suggests the inflammation is a result of yeast and if if we treat the yeast the inflammation would go away. Has anyone dealt with this topic of treating yeast (there are no signs except the inflammation) to deal with inflammation? Did you use Nystatin or Difflucan? Is anyone else seeing yeast impact inflammation? Thank you.

1/16/159:59 AM

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CTBarristerMember

I developed a severe yeast infection in my legpits and pubic area as a result of taking Entocort (like humira an immunosuppresant) and Cipro for a long period of time. The infection was resolved by taking Diflucan, rotating from Cipro to Xifaxin (not systemically absorbed) and keeping the skin areas I mentioned dry and by applying antifungal powders. An internal yeast infection is a whole different animal so not sure about it.

1/16/1511:22 AM

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Jan DollarModerator, RN, retired

Diflucan is typically used for internal Candida infections.

When I was on Humira, I had to take it weekly (one of the reasons I was happy to find an alternative). After a few years, even at that dose, it lost some effectiveness.

Jan

1/16/1511:27 AM

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boy's momMember

Thank you both. Jan - it sounds like you are suggesting humira gave you a yeast infection? Or you were more vulnerable because of the immune suppressing factor of humira? Our GI who only wants to give more humira (not even consider yeast) has not mentioned any link between humira and yeast.
I heard nystatin could be a safer drug than difflucan because of difflucan's impact on liver. Do you know why difflucan was always used and not nystatin? Thank you.

1/17/158:48 AM

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Jan DollarModerator, RN, retired

No, sorry about the confusion. I did not have yeast infections with Humira. I was just responding about what the treatment would be.

What I was saying was that I needed to take Humira weekly, and even at that higher dose, it eventually lost effectiveness. Since then, I've been on Simponi, and just switched to Cimzia last month.

Jan

1/17/157:46 PM

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ks1905Member

I've been on Flagyl and Entocort for 3 months now and I kept getting Thrush (yeast infection) which would make me really tired and my symptoms worse. They would treat me with a 7 day course of an anti-fungal and it would come right back. Finally I am on a continuous course of Fluconazole while on antibiotics or steroids. It has made a big difference in improving my symptoms and energy levels.

At first the Fluconazole would give me the worst diarrhea but after my body adjusted to it things have been good ever since.

1/29/1512:02 PM

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