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I've had a headache since May and we have tried everything to get rid of it. Last month my neurologist tried me on Topiramate, (the generic for Topomax), and while it did nothing for my headache, my pouchitis symptoms were completely absent for the entire month. I stopped it a week ago, and now I back on Flagyl. I have been trying to figure out how a migraine preventative/ anti-seizure medication could be so effective, at least for me. It did come with a host of side effects, particularly at the very high dose he had prescribed for me, so it is not a drug I would want to take long-term, but it does have me puzzled.

Anyone have any thoughts?
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Many of the anticonvulsants are often used for various pain syndromes, particularly those suspected to be neuralgias. Migraines can fit this category sometimes. I would suspect that some of your pouchitis symptoms are neurologic in origin, either from specific nerve irritation, or a generalized sensitivity. While you would not want to stay on Topomax because of the side effects, it might be a good idea to discuss it with your GI or surgeon that is treating your pouchitis. Perhaps something like Neurontin (gabapentin) might be a good fit for you. Flagyl is not good long term if you deveop peripheral neuropathy from it (common side effect).

Jan Smiler
Thanks Jan, I was hoping somebody could shed some light on this!

I am wondering though, my stomach doesn't work because my vagus nerve is malfunctioning, and I got a third opinion about my headache on Monday and he is concerned that the vagus nerve is also responsible for that. We haven't been able to pinpoint the cause of my esophageal problems, and now you are suggesting that my pouchitis could be nerve related as well? That is a very interesting thought and one that I am definitely going to run past my team of doctors!

You're awesome! Smiler

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