I have had my pouch since 2003. Cipro, Flagyl, tincture of op, and belladonna and op suppository keep me in check. The single biggest thing I have found for me (besides the meds) is water. I drink a minimum of 2 quarts a day. I am up 2- 3 times a night min. Keep a bottle on my nightstand and drink before heading to the bathroom. First thing in the AM I drink a glassful on the way to the bathroom. I spend a lot of my work day driving and keep a gallon in my vehicle to fill up my bottle. I drink weak tea every now and then. Caffeine has a definite bad effect on me. I am looking for others observations on hydration?