I had my first one on Tuesday. My pouchitis got so bad that in the summer I had to go back to an Ileo. After my second one in 2 weeks they are letting me get reversed. Yay!!! It's a 50 50 shot but my doctors office was in the trials and they are seeing very good results. It does take a while to work. You can try Remicade, that works fast, but less side effects with vedolizumab. I got very sick with Remi but it did work even when I stopped for a few years. Feeling hopeful with Entyvio. Go for it!