Switching meds from Humira to Rinvoq OR Skyrizi

I've been on a Humira biosimilar (Hyrimoz) in 2021, but it did not help me. I was on chronic antibiotics till last December. Then switched to Skyrizi (with initial prednisone tapering over 3 months) and my condition is very stable. Still about 6 BM a day. Inflammation levels (CRP) are normal.

I have to use the on-body-injector only every 8 weeks.

@Lisa MC

Skyrizi and Rinvoq have different mechanisms of action (targets) and there’s really no recommendation on which one to try after a TNF inhibitor (eg Remicade and Humira). Skyrizi targets interleukin-23 while a Jak inhibitor (rinvoq) works upstream and affects the signaling of several interleukins. Deciding between the two comes down to route of admin (oral or injection), risk profile of each drug (jaks generally avoided in those with significant cardiovascular disease) and  yours and your physician’s comfort level with each med. One upside to the Jak inhibitor is that they act very quickly so you’ll know if it’s going to work in a month or so which is faster than the biologics. Also convenience of the pill. If you try one and it doesn’t work you can switch to the next. You haven’t burned any bridges. Good luck!

Thank you. Dr. and I have decided to start with Skyrizi. Waiting on insurance approval and then will get scheduled for the initial doses.

I just had my first SKYRISI infusion. I was on Entyvio for over 10 years and it stopped working. Lots of inflammation, stricture, I’ve been pretty sick again. Good luck. I have nothing to report yet except lots of headaches.

Good luck, AllyKat. Hope the headaches go away. I am still awaiting insurance approval. Thanks for the comment.

Good luck.

i was approved in 3 days.