I use prescription nifedipine or rectiv(this one does cause a bad headache quickly but over time with more use this lessens) for anal fissures. Both creams are not cheap. Nifedipine is a compound and has to be mixed at the pharmacy and not all pharmacies do this and it is about a 60 copay for me and rectiv is about 120 copay (all depends on your insurance). I have tried tons of different creams when I am sore to no end, but these two work the best to heal the cuts. Also, lots of warm sitz baths also help ease the pain. You can also get a prescription cream that can numb the pain in the anal area. No fun I now. If you really need something fast, A and D ointment does help ease the pain a bit. Hope you feel better.