I don't think the short course of prednisone will do your pouch any harm. If you have any simmering pouchitis it could improve. I'm on a six-day course of prednisone right now (though a lower dose). About twice a year it's needed (at least in my life) for one thing or another. Is your doctor planning to taper it, or stop it abruptly? Tapering is most important after a longer course, but most docs do it routinely, perhaps out of superstition.