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Absolutely.  I fly fairly regularly and just had a 6 hour flight last week.  As others have mentioned I try and not eat much or eat something small that is binding a couple of hours before I go.  I normally also take an Imodium before I get on.  

I can usually end up going to whole flight without having to use a washroom.  Honestly, I think it is more mental than anything.  The first couple of flights all I could think about was when I would need to go.  As someone else mentioned do something to take your mind off it.  

As I enter the aircraft I ask the flight attendant if I can use the bathroom.  The response has always been, "Yes."  So, I turn left and open the bathroom door which is usually right behind the cockpit in the planes I fly.  I empty my J-pouch as best I can.  All of this only takes a couple of minutes.  I exit the bathroom and head down the aisle to my seat......always an aisle seat.  I stay hydrated with water and if I eat anything, I prefer to eat pretzels......salt helps me retain the water I drink!  I have flown several times to Asia from the west coast and have done so successfully.  I make it a habit to walk the aisles every hour.  Everything in moderation.  It works for me!  Best wishes!

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