I am writing to see if anyone out there has had the same experience that I had. In taking the tons of prednisone I needed to take, I awoke with the most intense pain in my knees one night in the hospital. I had to take pain meds to relieve the pain. Turns out, the prednisone had interrupted the blood flow to my knee, and therefore, oxygen to the knee was decreased and I have a small piece of dead bone in my left knee. I treat it with cortisone injections and I wear a brace designed to transfer the weight when I walk to the left side of the leg so as to decrease the pain on the right side where I have the issue. My future will hold a total knee replacement in 5-10 yrs. I am no longer able to run or even talk long walks. Is there anyone else out there who has had this happen?