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I have a brand new j pouch. Scanning these forums I am lead to believe that pouchitis is inevitable. I am taking VSL#3 probiotic which was recommended by my doctor as being the only one that has actually demonstrated prevention(http://www.ncbi.nlm.nih.gov/pubmed/14684584 for example).
I am curious to know about others' experience with this product. It's quite costly. Thanks in advance for sharing your opinioins.
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The thing is about VSL#3 is that it is the only probiotic that had been studied in regard to pouchitis, so of course, it would be the only one showing efficacy. Even then, it does not treat pouchitis by itself and does not prevent it universally. Other probiotics may or may not be useful, but any evidence is just anecdotal.

That said, this recent study I just found indicates that other probiotics may be beneficial as well:
http://www.ncbi.nlm.nih.gov/m/...uchitis%20probiotics
On the other hand, this Cleveland Clinic meta analysis indicated that VSL#3 was the only one to show a significant difference in sustaining remission:
http://www.ncbi.nlm.nih.gov/m/...uchitis%20probiotics

My conclusion is that it is a mixed bag. If you can get coverage through insurance, it is probably worth taking. Otherwise, I would not go broke over something that is not a sure thing. I have never taken VSL#3 in my nearly 19 years with a j-pouch, and I seldom get pouchitis. When I do, it quickly responds to a short course of Flagyl, which costs less than $10. I do take Align daily, but mostly for improved overall function, not pouchitis prevention.

Jan Smiler
Last edited by Jan Dollar

You will find some mixed opinions on probiotics. If you already have pouchitis, they most likely won't improve the situation, but there is some data that suggests they can prevent or delay pouchitis from developing.  As Jan posted, the only probiotic that has really been studied in pouch patients is VSL#3. Align has been studied and has been clinically shown to reduce symptoms of IBS, but again, there really isn't much data on its impact on pouchitis. That said, I personally take Align. I do not take VSL#3 as it is not covered in Canada and is quite expensive. I've been taking Align now for a little more than 3 years, and I feel it has been helpful, particularly in reducing gas. Prior to that, I took the Jaimeson 4-Strain probiotic, but noticed no difference whatsoever in pouch function. In the past I have had pouchitis, with my first bout 11 months post takedown. In recent years, I have had subclinical pouchitis, but no full blown pouchitis in over 4 years, and my most recent scope, which was just earlier this month showed that the pouch looked very healthy, so perhaps the Align is helping to keep pouchitis in check. That said, I started taking Align around the same time I also began taking turmeric, so it's hard to gauge which one has been most effective, or if it is a combo of the two that I am benefiting from. Overall though, since I have seen some improvements since starting Align and things appear to have remained stable, I have no intention of changing things up.

Last edited by Spooky

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