I don't know why but I waited for a year and a half after takedown to try loperamide. BIG mistake! This stuff has changed my life for the better. I avoid drugs generally and tried the metamucil type products initially and since that did nothing for me, I never even tried the loperamide. Finally I tried it when I caught a bug earlier this year and have been using it ever since. 1/2 to 1 pill a day is perfect for me. So in case you haven't tried it yet, I highly recommend it.