Yes and no. All of the biologics have a similar risk profile, but overall, the side effects are quite uncommon. I have been on one biologic or another for about 15 years and have had zero complications. I am careful in regard to exposing myself to contagion. The primary issue for me is simply the hassle of having frequent lab tests and having to come to clinic for infusions.
The upside is undeniable for me, as my chronic pouchitis resolved by being on the right biologic. I am currently on Inflectra and Entivio will probably be next when or if the Inflectra loses effectiveness.
Jan