I've been on antibiotics for about 6 years for pouchitis, with excellent results. Because I couldn't find an assortment (or even a pair) that worked, cycling/rotating wasn't really an option for me. I've been on Cipro essentially all of that time, and added Flagyl a couple of years ago when Cipro alone lost efficacy. I've been careful to find the lowest effective dose, and of course I've been lucky.

Thank you, Scott!  That's really good information.  Yeah... we all have to factor in luck.  Glad it's working for you!  Cipro, for me, is much easier to take than Flagyl though I know some people say otherwise. I am starting Cipro right now and may perhaps just stay on. 

My son has had fistulas for a few years now.  In our experience, the antibiotics have not worked.  However, his fistula is all internal and he has an abscess as well.  

I was on antibiotics for a year, and they really didn't seem to do much for my fistula.  Time and a seton seemed to help more than anything as far as my fistula was concerned.  (However, still have it after 5+ yrs). 

I've been rotating Levaquin and Xifaxin (2 weeks for each, then swap) for about 4.5 years for poichitis. After using entocort on top of that but being unable to wean off without flare, I stopped that and added Immuran (while continuing to rotate the antibiotics) -that's been about 2.5 years on that combo now and all is working great!