Is there really success with biologics and Jpouch?
I know it works well for people that actually have UC & Crohn’s but it’s hard to find a good number of people that have success with the J pouch. I just finished my third biologic and absolutely no success.
just curious as to how many people on this site take a biologic with success.
Thanks
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Plenty of folks have certainly reported success here, but it’s very hard to reliably estimate the rate of success without a clinical trial. It’s helpful to keep in mind that folks experiencing success often choose not to spend their time reading and posting on a support forum.
It is true that results specific to the j-pouch are difficult to find. Most research goes into treating disease before collectors and much of the info is either anecdotal or small study groups. It seems like it is sort of an orphan disease. The bulk of IBD sufferers still have their colons. There have been studies that indicate that in the future they may be better able to predict who will respond to any particular treatment. This will be based on DNA analysis. But we aren’t there yet.
For now it is important to know that there myriad variables that play into j-pouch diseases. Frustrating? Yes. Like whack-a-mole. You just have to keep swinging, or give up and ditch the j-pouch. No perfect solution, and definitely no solution that works for most people. I went through 4 biological before landing on Remicade, which works for me (for now).
Jan 
Hi,
I started with Entyvio almost a year ago in March. I believe it has helped me. I did have a Dilation in June which also greatly improved my situation. I feel like the Entyvio wears off when I’m about 1-2 weeks away from the next infusion. I used to suffer with pouchitis and I haven’t had a flare of that for over a year!!
All the best to you!
