Skip to main content

Ischemic pouchitis: Pouch ischemia may also be a cause of pouchitis. Characteristically, ischemic pouchitis is more often found in the efferent limb of the pouch[27]. Factors related to the surgical construction of the pouch have been implicated, including disruption of the vessels supplying the distal ileum during colectomy or the tension of the mesentery and/or the vessels that supply the distal ileum during the IPAA construction. However, besides the mechanical factors, the underlying disease may also play role, since ischemic pouchitis is more common in UC patients than in those with FAP[28]. Ischemic pouchitis may also be related to oxidative stress of the endothelial cells, due to ischemia-reperfusion injury, which eventually results in inflammation of the pouch mucosa[29]. Patients with IPAA have lower plasma concentrations of lipophilic antioxidants (alpha-carotene, beta-carotene and lycopene) and higher free radical activity suggesting increased oxidative stress[29]. Patients with ischemic pouchitis are often mis-classified as having chronic antibiotic-refractory pouchitis. Most of these patients have minimal symptoms, and do not require management.

The article describes this type of pouchitis as "secondary," and the definition leads you to believe it is not a direct result of the underlying auto-immune issues (mechanical factors such as how the pouch was made).

From: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528017/

Last edited by ElmerFudd

Add Reply

Post
Copyright © 2019 The J-Pouch Group. All rights reserved.
×
×
×
×
Link copied to your clipboard.
×