I'm curious too about how inflammation works. I have had a pretty sever 'inflammatory' reaction to humira and I'm wondering too if there is anything I can do to reduce systemic inflammation (other than the prednisone I'm already taking).

Rebel, I'm sorry I can't provide any info re brain and spine (although that is my worry as well). 

Inflammation doesn’t spread. It can sometimes develop in more than one place, but it’s just the body’s immune system going to work (sometimes in the wrong place at the wrong time, with destructive results).

Great question....I have been having ALOT of trouble as of lately leaking at night, frequent frequent (alot) of bathroom trips lol ...have to try an find humor as I'm writing because literally I don't sleep much at all an is sending me on an emotional rollercoaster smh.  Recently went to the eye doctor an he seen inflammation during my eye exam so he sent me to see an ophthalmologist to get a field test etc., then he says the same thing an said I needed to have an mri because of the inflammation of the...so long story short I had the mri of my brain and they said it came back normal...but now suggest that I see a neurologist to get a needle in my spine forget the correct term to check to see why there is an elevation of pressure I guess an the inflammation....sooo Idk whats next.  I was wondering the same thing about inflammation of the spine.