Flagyl tolerance and mesalamine suppositories

Although I am not optimistic about that treatment regimen, it was suggested to me in the past. For me, cipro and flagyl was the best tandem and Visbiome or VSL#3 as it was formerly known never did a thing and I got worse while on it. I was also on mesalamine suppositories and enemas. Both were completely ineffective.

I think your husband is probably right where I was in around the year 2000. Eventually there will be too many pouchitis rodeos, there will not be a permanent fix and biologics will be suggested. I of course hope that's not the case, but it's possible as a large number of chronic pouchitis folks end up on biologics. I have been on Remicade since 2015 with very good results. Pouchitis was mostly eliminated with some persistent inflammation at the J pouch inlet from backsplash stool. If at some point your husband isn't happy with the results of antibiotics and probiotics, biologics are the next line of treatment. For me, Remicade has been far more effective than antibiotics and probiotics.

I do well with antibiotics (Cipro + Flagyl) and VSL #3 together, but I’m lucky enough to have no major side effects. 

Here’s a savings program for Canasa suppositories. I’ve saved an enormous amount of money (on other meds) with this sort of program, and I hope it works for you: http://www.canasa.com/en/canasa_patient_savings