There are many, many different antidepressants around. They aren't likely to all have the same side effects.

Have you had any specific treatment for the fissures, like nitroglycerine cream, nifedipine cream or similar treatments? There is also Botox injections or even a sphincterotomy. If your GI has determined the fissures are not going to heal, he should give you a referral for other treatment. You should not accept this sort of pain as a lifestyle!

You are doing what you can on your own, and it is not enough. The only other self help suggestion I have is sitz baths for the fissures and an elimination diet to try to better control your output.

I definitely would get a second opinion. Plus, you should get sedation or at the very least, topical anesthetic for scopes with these fissures.

Thank you so much, Jan! Two yrs ago when GI diagnosed the fissure/s on scope, I was told it was something I would have to accept. So I did (in order to cope). My husband died the same time; it has taken two yrs for me to start "thinking" again. We were both sick trying to care for each other. I was healthy up until UC at age 61.
No, I have not tried any of those medicines u suggested. But I will. I am so thankful I posted this today.