I am wondering how others have responded to Entyvio. I have just been approved for it and am concerned about side effects. Have used Humira in the past but it stopped working. Also, tried Remicade but had a severe allergic reaction. Is there anyone here that has experience with Entyvio? I work full-time and don't want to miss any more work due to drug reactions, etc. Thank you.
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In reading the NEJM study on this drug, it appears there were very few adverse reactions to this drug. The scariest appear to be avoided by how the drug works, and it seems that allergice reactions are very rare. Sounds like a promising drug for UC, in particular!
Hi ElmerFudd,
Thanks for your reply which is encouraging. Do you recall the title of the article? I'll search for it at the University library.
Thanks for your reply which is encouraging. Do you recall the title of the article? I'll search for it at the University library.
Does this work for 'crohns of the pouch'?
I was on Entyvio (Vedolizimab) for a year or so for UC. It is an experimental drug here in Oz (so it was part of a trial, not blind so 100% guaranteed of getting the drug). Within two weeks of the first infusion I was in complete remission. This was fantastic. 12 Months later I had a colonoscopy which further confirmed the remission. Two weeks after that saw signs of blood and mucous and within a month UC was back. I was told there were patients who had been on it for several years and maintained remission. I was also told that, for patients where it worked quickly, it seemed to lose its efficacy after a year or so (me I guess). So nothing working and essentially now pan-colitis after only being 25cm-35cm for many years previously. Colon removed 9 July 2014, takedown 15 October 2014.
I do not know if the colonoscopy unsettled things, my GI says no, but appears to be too much of a coincidence (conspiracy theory).
Note also that is not guaranteed to work, I believe there is something like a 65% (don't quote me) success rate and much better than Humira. Regardless, when it was working, it was working 100% and there were no side effects. Some of the major side effects of the other biologicals are not evident in Vedolizimab so I wouldn't worry about using it (not a medical opinion).
Good luck with the treatment.
I do not know if the colonoscopy unsettled things, my GI says no, but appears to be too much of a coincidence (conspiracy theory).
Note also that is not guaranteed to work, I believe there is something like a 65% (don't quote me) success rate and much better than Humira. Regardless, when it was working, it was working 100% and there were no side effects. Some of the major side effects of the other biologicals are not evident in Vedolizimab so I wouldn't worry about using it (not a medical opinion).
Good luck with the treatment.
Here is the NEJM article: http://www.nejm.org/doi/full/10.1056/NEJMoa1215734
Regarding Crohn's and Entyvio, it was not proven to be very effective. Not sure about "Crohn's of the pouch" - wasn't tested:
http://www.nejm.org/doi/full/10.1056/NEJMoa1215739
Steve
Regarding Crohn's and Entyvio, it was not proven to be very effective. Not sure about "Crohn's of the pouch" - wasn't tested:
http://www.nejm.org/doi/full/10.1056/NEJMoa1215739
Steve
Hi Steve,
Thank you for the reference. I will check it out. My first infusion is tentatively set up for 2 weeks from now. Nervous about trying a new drug.
Barbara
Thank you for the reference. I will check it out. My first infusion is tentatively set up for 2 weeks from now. Nervous about trying a new drug.
Barbara
Kevin,
I really appreciate your feedback and support. Hope you are well.
My first infusion is coming up soon.
I really appreciate your feedback and support. Hope you are well.
My first infusion is coming up soon.
It is funny that I was just about to through out the question if anyone has tried Entyvio. I was just at my rheumatologist and he asked me to ask my gastro about Entyvio but I don't know if that is for us j-pouchers. Is there any j-pouchers out there that is on this and if there is how are you responding to it I have J-pouch due to Ulcerative Colitis taking antibiotics every day due to chronic pouchitis Thanks Grace