Before my UC diagnosis  my GP either gave me antibiotics or antidepressants as he told me both made up over 75 % of his prescriptions .I listened to him and before my uc diagnosis my sleep,skin,mind were a terrible mess.but nearly a year out from my takedown surgery my skin,mind and sleep have improved  massively. My doctor apologised to me but I don't forgive him for not taking my temperature or checking my tongue.even now he just asks me whatever I need he will prescribe it

I have gone cold Turkey on the 10mg of lexapro I was prescribed  that definitely  helped the jpouch journey.

the light headedness is amazing but was told it should last 3 weeks.but healthy guts equal healthy skin,mind and sleep.

@Chook2 posted:

Before my UC diagnosis  my GP either gave me antibiotics or antidepressants as he told me both made up over 75 % of his prescriptions .I listened to him and before my uc diagnosis my sleep,skin,mind were a terrible mess.but nearly a year out from my takedown surgery my skin,mind and sleep have improved  massively. My doctor apologised to me but I don't forgive him for not taking my temperature or checking my tongue.even now he just asks me whatever I need he will prescribe it

I have gone cold Turkey on the 10mg of lexapro I was prescribed  that definitely  helped the jpouch journey.

the light headedness is amazing but was told it should last 3 weeks.but healthy guts equal healthy skin,mind and sleep.

Your lucky, doctors barely apologize

Thanks for the story Chook.

Does anybody have an answer to my question? Does our J pouch start to create serotonin like the guts that we no longer have? I’m talking natural serotonin not from a pill. Thanks again!

is the serotonin produced in the gut finds its way to the brain, or is it for the nerves in the gut itself?

https://pubmed.ncbi.nlm.nih.gov/29803758/

https://pubmed.ncbi.nlm.nih.gov/22922006/

https://cme.lww.com/files/IBDL...BD-1492622933861.pdf

Hope this helps hon

Good question. Anybody know about all this? It would be really helpful.

@tulsamom posted:

Good question. Anybody know about all this? It would be really helpful.

I would check out the links I posted above, hope that helps

Oh thanks Lauren! I didn't see those.

@tulsamom if the serotonin produced in the gut in normal people does not have any effect on the brain, but is solely produced for the colon to function properly, there are millions of neurons there after all, then you should not worry about depression due to lack of serotonin produced in the gut.

Totally. Is that what you got from the articles? That the serotonin in the guy doesn't go to the brain it affect the brain at all? They were pretty complicated and not studies specific to that question. More related to IBS and different levels of a functioning pouch. But I was glad to see that out pouches do adapt to make serotonin.

@tulsamom posted:

Totally. Is that what you got from the articles? That the serotonin in the guy doesn't go to the brain it affect the brain at all? They were pretty complicated and not studies specific to that question. More related to IBS and different levels of a functioning pouch. But I was glad to see that out pouches do adapt to make serotonin.

Yeah the human can adapt to anything, that is what makes us different from trees.

@tulsamom posted:

Thanks for the story Chook.

Does anybody have an answer to my question? Does our J pouch start to create serotonin like the guts that we no longer have? I’m talking natural serotonin not from a pill. Thanks again!

Serotonin is produced by Enterochromaffin cells (EC), among other cell types, in the gut including in your small intestine. Bacteria don’t make the serotonin in your gut though the interaction between microbes and the ECs are important to their function. ECs can be stimulated to produce serotonin by a number of signals like mechanical stress, microbes, the content of your meal (e.g glucose). The serotonin produced acts locally in your enteric (gut) nervous system to regulate peristalsis, inflammation, etc. This serotonin does not act on your brain. There are a number of other signaling molecules/hormones in the gut but serotonin is a major one.  It’s a very complex and impressive system though as we all know here, much can go awry.  The short version. You still have ECs in your small intestine cranking out serotonin. Your pouch doesn’t need to “learn to make it”. But again that has no bearing in levels in your brain.

Thank you so much! So interesting and now I finally understand. I really appreciate you explaining it in a way I could understand. 😊