For those of you who have taken Imodium for many years, does it lose its effectiveness over time? For example, I only need 2 a day but will I eventually need more to get the same effect?
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For me it just stopped working.
I am very sensitive to the effects of Imodium and need only 1 gelcap to have a profound thickening effect, and have never had to increase dosages due to tolerances being built up, during the times when I was taking it daily.
Thank you for your responses!
Imodium and Lomotil are not the same.
I’ve been taking both for years. I have to say that since the Pandemic I’m having a rough rime finding Bottles of Imodium.
I can only find them in the blister packs. Even going to the official Imodium Site.... it says that Amazon and pharmacies carry bottles of 30 and 45 but they don’t. I even spoke to Johnson and they couldn’t find an answer.
Two cents here Kangaroo....I have found that some batches can get "old" and not work as well. Definitely. Esp. the bulk ones would seem to lose efficacy towards the end of the bottle or in humid/hot conditions. J pouchers notice these things!! 
My compounding pharmacist told me to always keep them sealed in the (WORST) blister packs ever. It stinks that the limit now is 24 caplets per box due to the loperamide abuse that a very small subset of opioid users were using but you can still buy 10 boxes at a time. LOL. Thanks FDA. The liquid gel caps are easier to open!! sorta.
All of them are sold with expiration dates and you should not buy a supply that you can't use up before any expiration date.
Ccolbymontucky - that's interesting what you say about bulk bottles and not being as effective. I'm currently towards the end of bottle with 200 pills and it doesn't seem to be working as well. Now I'm thinking it might not be the loperamide but the fact that the pills aren't as fresh. The pills are well within the expiration date.