i think it's better to go off or you might become resistant to it.  you might consider switching between augmentin, xifaximin or levaquin, which is in the cipro family.  that said, consult with your doc about this.  pouchitis is nasty!  one thing that helped me is no--that's NO--refined sugar and shellfish.  everybody is different , but i've heard the sugar problem with others.  once off it you'll never go back!!  really.  good luck,jlh

If I could go 2-3 months symptom-free without Cipro I'd definitely take the breaks. You might want to pay very close attention to when symptoms return, so you can restart the treatment without delay.

I was doing pretty good until I overdosed on potato chips. As a result, I am fighting a nasty case of pouchitis at this moment. Just awful when it hits. Sugar too bothers me.

I would tend to think that going off when possible would be best. it does seems like many meds you can build a tolerance for them, rendering them less effective over time. when my dx first was changing to crohns, we tried rotating three antibiotics on a monthly basis, Flagyl, Augmentin and Xiafaxin. it didn't work for me and I ended up with an allergy to Augmentin. I finally went on Remicade which I had resisted initially and when that kicked in it was wonderous. I wonder if your doctor might eventually consider a reevaluation of your dx. my doctor said to me about ten years ago, well it would seem by clinical observation that you have crohns not UC. my resistance to starting Remicade likely resulted in me developing two strictures, one mid pouch, one above the pouch entrance from the crohns. just a thought, don't want to raise the alarm but sharing my experience and my regret. good luck. I love all manner of chips, and sadly have a sweet tooth as well, but from what I can tell neither of those fortunately seem to cause any issues whatsoever for me.