Good luck. I know it is difficult to be patient when you are struggling with uncomfortable symptoms and not knowing if there is a relationship between those symptoms and your treatment.
I have not personally taken any antidepressants, but know many who have. Sometimes there is an immediate positive effect, sometimes it can take a couple of weeks before you see it. Also, sometimes it is the people who are close to you that notice the difference in your attitude and affect, before you do.
I have a friend whose husband suffers from severe depression. He felt like the antidepressant wasn't doing anything and he was worried sick about his liver (his grandfather died from liver failure). But, as the wife, my friend said he really was a different person and easier to get along with, even if it was not perfect. But, her husband felt like it was "fake happy," and wanted to stop the treatment. This is putting a real strain on their marriage, as you can probably imagine. Takes two to tango... I am hoping my friend can convince her husband to stick it out, and maybe that "fake happy" will turn into real happy over time. I wonder if he has been depressed so long, it feels wrong to feel happy and he needs to get out of that "loop" of unhappiness.
I have no idea if this applies to you, but maybe you can ask your wife to tell you if SHE sees a difference when you are taking the antidepressants.
Jan