Re: Canasa and JPouch

OKSTFANMember

I found that Canasa is really helping me with my Pouchitis. As a matter of fact, the last 2 scopes showed no problems in the J-Pouch. That is after 1 doctor a couple of years ago telling me I needed the pouch removed. I give most of the credit to Canasa.

Has anyone else had any experience with Canasa? By the way, I am also on Uceris and Endocort tablets.

9/3/145:23 PM

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CTBarristerMember

Are you taking Canasa enemas or suppositories? I could never hold the enemas.

9/3/148:14 PM

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Jan DollarModerator, RN, retired

Canasa are suppositores only.

Jan

9/4/1412:13 AM

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CTBarristerMember

Jan-

Isn't mesalamine the same operative ingredient in Canasa suppositories/Rowasa enemas/Pentasa capsules/Asacol? A lot of times on this board people mention different brand names of the same drug.

9/4/147:00 AM

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Scott FMember

Canasa is indeed mesalamine rectal suppositories, and Rowasa is mesalamine enemas. Same active ingredient, different delivery method.

9/4/149:01 AM

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CTBarristerMember

I have used the mesalamine suppositories and enemas and neither work. They are also pointless if the problem/inflammation is located at the J Pouch inlet or above the inlet and is due to bacterial overgrowth and backwash stool. That being said I am taking mesalamine orally (Pentasa) which seems to help somewhat and that delivery method is best for me.

If the scope identifies a problem in the cuff or in the rectum exclusively I can see the suppositories being helpful. However in my opinion this treatment should be targeted based on what the scope is showing and for inflammation higher up or SIBO it seems unlikely to be of much utility.

9/4/149:42 AM

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Jan DollarModerator, RN, retired

Rowasa used to come in suppository form in addition to retention enemas, but they stopped making it about a decade ago. The Canasa brand is the only mesalamine suppository currently in the U.S., and there is no generic. It also is twice the concentration than the Rowasa's were; 1000mg vs 500mg. Salofalk is an available brand in other countries.

Whether or not people use the brands interchangeably, I don't know. Sometimes it does not matter, but in this case, Canasa is suppository only.

Jan

9/4/1412:15 PM

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Jim SMember

I had my j-pouch done in 1987 and have only had a few brief episodes of pouchitis. The latest scope a week ago showed inflammation and ulcers which surprised me because I did not have the typical symptoms. So, Doc started me on Canasa. I find it interesting that I was on the clinical trials for Asacol in the early 80s and it really didn't help the UC. Hoping for good results this time around.

1/30/1610:28 PM

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n/aMember

I've been using canasa fairly regularly (from daily to 3 or 4 times/week) for cuffitis, for about 5 years now. While most of the time I am symptom-free, my last EUA/scope showed erythema and ulcers in cuff, and ulcers in pouch. This is typical for me. My pouchitis still recurs 2-3 times/year. My biopsies have shown the Crohn's markers (granulomas, etc.), so there is that complication.

I like to think the Canasa is helping at least to keep some of the cuffitis symptoms at bay, and maybe prevent things from worsening in that area. Am not sure about whether it affects the pouch. However, I am most definitely planning on continuing it, unless I am moved to Pentasa or a different med.

1/31/161:10 PM

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