Quick answer: yes and yes.
I had pouchitis from the first post-j-pouch surgery check-up and continuously for 8 years. Was on cipro + flagyl for 2 weeks and off for 2 weeks for years, alternating between 2 weeks of nausea and then 2 weeks of pain/urgency -- month in and month out.
After 8 years I was so miserable I had a k-pouch created at CC -- that was almost 12 years ago and I am better off now. Diet limitations are easier to take than nausea or pain and urgency, at least for me.