Hi Sara, as I might have been the trigger for this thread, I'd like to tell my experiences so far.

I took sodium butyrate more than 10 years ago for several weeks to treat my chronic pouchitis. I managed to abandon budesonide during that time (which always resulted in increased inflammation when I tried reducing it before). I took the butyrate as an oral supplement most of the time, the recommended serving of 3x2 capsules a day with 600 mg of butyric acid per capsule.

I used it only on few occasions to do an enema, mixing the powder of 3 capsules with 100...200 ml of water.

I got some kind of stomach flu back then, and afterwards the positive effect of taking that supplement was almost gone.

I started a treatment two times in the years afterwards, but I didn't see the significant effect as at the first time. Right now I'm trying again after reading the thread about warm water enemas. But it's too early to tell if it makes a change. I'll report on that later.

@SteveG posted:

I started a treatment two times in the years afterwards, but I didn't see the significant effect as at the first time. Right now I'm trying again after reading the thread about warm water enemas. But it's too early to tell if it makes a change. I'll report on that later.

Hi Steve, how did things go with this?  You weren't actually the trigger for me considering sodium butyrate.  I stumbled across it while researching about gut helpers on the web.  I found positive studies like this one:

https://www.ncbi.nlm.nih.gov/p...y%20for%2012%20weeks.

This website also mentions a lot about the benefits of sodium butyrate, and cites a number of studies in humans. 

https://health.clevelandclinic.org/butyrate-benefits

There have been a ton more studies in animals, too.

I have been taking sodium butyrate since July of 2023 (sometimes off but mostly on) and I believe it has decreased some of the irritation I get near the anus.  I have had decreased severity and length of irritation of hemorrhoids and fissures.  So that's something!  I don't know if I can definitively attribute it to the sodium butyrate, of course. 

I hope to hear how your experiment went!

Hi Sara, the effect of sodium butyrate again wasn't clear enough for me last year. So I stopped it and simply continued with antibiotics and probiotics. Since December I'm on a new biologic treatment.

Still got some supplies of sodium butyrate here, so maybe I'll give it another try.

Good to hear that you experienced some positive effects.

@SteveG posted:

Hi Sara, the effect of sodium butyrate again wasn't clear enough for me last year. So I stopped it and simply continued with antibiotics and probiotics. Since December I'm on a new biologic treatment.

Still got some supplies of sodium butyrate here, so maybe I'll give it another try.

Good to hear that you experienced some positive effects.

Hello and thanks for the update!  What is the biologic you are taking?  What have your symptoms been that you have had to take antibiotics, probiotics, then the biologic? Has it been pouchitis?  Sounds like the antibiotic/probiotic approach was insufficient for your ailment. Do you still have any symptoms after starting the biologic?  I am curious about these things called biologics.  They have an attractive and yet somewhat scary name. 

I have been taking antibiotics + probiotics before for about 3 years, for chronic pouchitis. That way inflammation was reduced widely.

My doctors recommended to try that biologic called Skyrizi, and as my liver labs were far beyond normal (maybe as a side effect of antibiotics) I agreed. So far I'm ok with it and my liver labs have normalized.