Herb: biopsies that show some mild inflammation are irrelevant. I have had a J Pouch for 30 years and have had 30 years of biopsies showing inflammation. Unlike you, however, my inflammation is visible on scope and needs to be treated. A biopsy that should worry you is the one that shows dysplasia in your rectal cuff. I presume they biopsy your and everyone else's cuff on scope because that is the only colonic tissue in your body and the place where a cancer is most likely to start, although they are very rare in pouches.