A promising study, one artcle mentioned upto 60% could be lost going through the GI tract. This study does not compare oral vs enema for efficacy.

https://onlinelibrary.wiley.co...65-2036.2011.04939.x

Logically enemas should be more beneficial for pouches. I will give it a go to see if better results.

I'd be interested to hear how this works out!

A few folks have posted over the years about trying this. It’s very difficult to measure efficacy of probiotics, and one person’s results could easily be random variation. I wish Bo Shen were more interested in probiotics, since he’s one of the few people who could test this properly in a clinical trial. Heck, maybe he has - negative results are very hard to get published.

I

@Scott F posted:

A few folks have posted over the years about trying this. It’s very difficult to measure efficacy of probiotics, and one person’s results could easily be random variation. I wish Bo Shen were more interested in probiotics, since he’s one of the few people who could test this properly in a clinical trial. Heck, maybe he has - negative results are very hard to get published.

Thanks Scott.
I will report back here.  Ultimately I want to see if there is an improvement and, secondly, whether I can lower the dose to maintain a level.  Using half the amount of VSL3 will save a lot of money.  It will all be subjective

I have been using warm water enemas for 6 months and it has changed everything for me. I use the enema twice a day. I had trouble emptying pouch,which means a lot of trips to bathroom. I went from 10 -12, to 4-6 trips using enemas. I am changing over today to distilled water and I am going to put a dose of probiotic in enema. I haven’t been able to take probiotics as they upset my intestines/stomach too much. It just make sense to deliver meds where they are needed. Changing to distilled water will eliminate any chlorine and other chemicals. Will report back in a few weeks on how well they work.

That's good to know.  I must admit my use of enemas has been on and off, so I cannot form an opinion yet.

@Bill K posted:

I have been using warm water enemas for 6 months and it has changed everything for me. I use the enema twice a day. I had trouble emptying pouch,which means a lot of trips to bathroom. I went from 10 -12, to 4-6 trips using enemas. I am changing over today to distilled water and I am going to put a dose of probiotic in enema. I haven’t been able to take probiotics as they upset my intestines/stomach too much. It just make sense to deliver meds where they are needed. Changing to distilled water will eliminate any chlorine and other chemicals. Will report back in a few weeks on how well they work.

Hi  Bill!  What kind of probiotic will you put in the enema?  I agree that it is a good idea to use filtered and/or distilled water to avoid chemicals.  I also wonder if aloe applied via enema would have a positive effect.  I eat it sometimes for inflammation and also apply it to my skin, but I never thought about putting it in the other way.  It might be interesting!  I would only be worried about the lemon juice that most aloe gels and juices are preserved in.  Probably would be best just to get some gel straight from the plant.  Not the most convenient, though.  I look forward to hearing about your probiotic experiment.