Magnesium helps with restless leg syndrome.might help.

When I get cramping in my calves, it means I’m dehydrated. I usually drink unflavored Pedialyte. Gatorade has way too much sugar and not enough Electrolytes for me.

Magnesium is usually the culprit.  I have had to have infusions before to deal with this issue.  It is painfully annoying.

Hydration! Speaking of which at my last Remicade infusion I showed up not properly hydrated and it took a record 11 pricks before they found a vein. Prior record was 8. Now I have hematomas all over both arms, as well as a very painful wrist prick that was also unsuccessful and left a mark. Hydrate!

I know it hurts, I have magnesium supplements, can also be dehydration and in the hot Queensland summer drink 1 or 2 glasses of Hydralite, that helps alot and will probably help your daughter doing sports, a quick replacement of electrolytes on a regular basis really helped!

I agree with the above responses as my daughter has this and I gave her magnesium glycinate before bedtime. She takes this most every night and legs feel better and she sleep better too!

Thanks all! I will work with her on the hydration. She thinks she drinks a lot but likely does not. Her GI did blood work, and her iron was the very low-end of normal, but that doesn't usually result in muscle cramping but still needs to be addressed. Potassium, calcium, and magnesium were all normal:

Potassium 4.4 mmol/L  Ref Range: 3.5 - 5.2

When my iron levels were low I was experiencing restless legs and cramping especially at night.

Ahhh... good to know. Hopefully that's her issue then Flintstone vitamins with iron

Hello I've Had my pouch for 22 years and have calf cramps often and it was hydration (lack of it). My Dr. Said drink water and v8 juice. It helps alot and works for me, Get the low sodium if you can.

Thanks @HDMan. So far, so good with better hydration, some time off constant soccer practices & games, and the addition of iron with the vitamins. She said her legs aren't cramping right now during games - so that's progress

I had leg cramps really bad and a friend told me she started taking B12 supplements. I take it now before bed and rarely have leg cramps anymore.

Thanx Ceew it is good to know what has helped others. It's been in the high 90's for the last week or so and I've struggled with hydration and cramping too.

Hmmm... yeah. I don't think they regularly check for B-12 in my daughter's blood work. We started having her take additional magnesium, potassium, and calcium and it hasn't completely eliminated the issue but has helped. She also switched to Inflectra (bio-similar for Remicade) and should be stopping her Colazol end of week, so hopefully any absorption issues will resolve. But I might suggest testing her B-12. Thanks!