Hi Adam,

I take loperamide 3x/day

breakfast, dinner and bedtime.

Couple with my last meal no later than 6pm I get good results.

I am up 3-4 times per night to urinate, but as long as I have no gas, no BM either.

my GI would like me to reduce the dosage, but has not provided an alternative. Since I am finally in a good place I am sticking with and accepting the loperamide as a long term therapy.

Adam, a small fatty meal (like a spoonful of peanut butter) at bedtime sometimes helps more than you’d expect.

Pepto Bismol is worth a try - Doctor Shen recommended it. Have been taking Loperamide around 8 pm to settle my "every evening gut excitement" then Pepto 3- 4 hrs later. I've had a few good 6hr nights. (4 hrs at a time is my base line though some nights even that is interrupted. )  Take a look at other comments here by searching Pepto Bismol. Beware the black stool and tongue.

Diet seems to be all-powerful. I've shifted to a small meal, never late, oatmeal is best. I've tried Scott's Peanut Butter thing when I'm feeling particularly hungry but it's too late to eat too much. Seems to work.

Hoping things continue to improve as I approach the 1 yr mark in June. And wishing continued improvement for you.

Pepto works for me. Twice a day extra strength. Eat something like thick potato soup, a bagel or rice at night. Red meat takes a really long time to digest, so steak & potato dinner is best for me.

I take loperamide with dinner and then at 11pm before bed. But I also take Colestipol, one with dinner and one before bed. My doc says it works completely different than loperamide but it slows things down. Works great. I can sleep from 11pm-5/6am. Ask your doc about this medicine. Here’s more info