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I finally took my first 2 Simponi injections today.  I followed the instructions closely and chose to inject them into my abdominal area about 1-2 inches from my belly button - one injection per side.  The first one worked as I believe it should have.  When injecting the second one, I heard the first click as I squeezed and then heard the second click just like my first injection.  However, after the second click, I pulled the injector from my skin and a fair bit of fluid streamed out of the needle.  Not sure why.  There was also a little blood at the injection site after the second one.  I then contacted the nurse with the drug  company and she believes that maybe I did not get some of the medicine into my system.  I told her I have no idea how much went into my system and how much didn't.  She offered to get me another dose of Simponi but I am not sure what to do.  At over $4,600 / shot, you want to make sure it gets into your bloodstream....

On another matter, I have been having a lot of strange "inflammation like" ailments over the past few months.  The past 3 or 4 days, when I wake up in the morning and get up, the upper part of my right calf muscle is extremely painful when I walk.  In fact, it causes me to walk with a painful limp. After a couple hours, it loosens up and the pain subsides.

This is a really strange thing.  I don't think I injured it.  Can anyone relate?

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I don’t know why the injection malfunctioned, but I wouldn’t worry too much about it, especially since it was your first dose. If an appreciable amount of medication was wasted then the Simponi will just take a bit longer to work for you, and if it turns out to have been a small fraction then the effect will be insignificant.

When I first tried Remicade many years ago I asked the nurse to flush the line with the last of the Remicade into me, since I figured the tubing contained several hundred dollars worth of medication. I knew I was being a bit silly, but she agreed to infuse every drop.

Scott F

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