@Almac posted:

After about 2 days of cipro for pouchitis, I get essentially blocked up to the point of gas being painful. Amoxicillin doesn’t seem to have any effect. Metronidazole leaves me wondering if it’s making me sick or helping. Rifaximin does the same as cipro. Bentyl made me a nervous dry mouthed mental wreck. A year ago I did 3 hospital trips that started like this and went through all those during that. Since then I’ve been on probiotics and done great. So I’m disappointed for this setback of nausea fever and diarrhea.

And I did get tested.....I’m Covid negative.

Anyone have experience with Tinidazole? Or similar experience and advise?

Tinidazole was a core antibiotic in my rotation. However unlike you I tolerated all of them well and they all worked well on symptoms before I finally went on Remicade and put antibiotics in my rear view mirror. I believe tinidazole is in the same antibiotic family as flagyl aka metronidazole.

BTW Bentyl is an anti-spasmodic, not an antibiotic.

If the Cipro (and rifaximin) are just making the stool too thick to pass comfortably, perhaps they would work acceptably if you took some steps in advance and during treatment to offset that effect. Some possibilities include 1) drinking lots more water, and maybe adding grape juice, 2) stopping all bowel slowers (Lomotil and Imodium) if you take them, 3) tinkering with fiber dose (it’s often recommended for constipation) or stopping it, 4) adjusting your diet to reduce/avoid binding foods.

Finding an antibiotic that just works for you easily is best, of course, but sometimes “simple” side effects can be managed.

Yeah Cipro has a tendency of thickening up stool. I Definitely increase water intake as much as possible. I think that can possibly help your situation, also moving around as much as possible.