Kk, when you write “upper right corner of cuff” I get concerned that you may be misunderstanding what and where the cuff is. Perhaps I’ve misunderstood, but just in case: The rectal cuff is an internal structure, generally at about a full finger length inside the anal opening. If you are having pain at/around the anal opening that’s more likely to be an anal fissure than pain from cuffitis. You can have both, of course, but they call for different treatments.