It is likely to pass through your system before it fully dissolves. My system is definitely fast enough that almost any time released meds don't work properly. If you have a very slow transet time with things you eat you may be ok. Most pouchers are told this about time released meds/vitamins.

Most extended release medications become unreliable without a colon. Some are designed to fully absorb in the small bowel, and those might work, but I wouldn’t count on it.

Just depends on the XR formulation of the particular med.  I’d poop out undissolved 60 or 80 mg oxycontin, but never had this happen with 300 mg Wellbutrin XR.
If you’re finding pills or caps in your stool, you need shorter acting meds, perhaps liquid, transdermal or sublingual formulas.  

I don’t think the presence or absence of whole pills in the stool is a reliable indicator of whether the medication is working as intended. The durable portion of an extended release formulation can be quite small.

Someone on this site mentioned an apple-cider vinegar test where you drop the pill into the vinegar and wait 20 mins...if it doesn't dissolve then it will not dissolve in your gut...I am not sure how reliable the test is or if anyone has tried it but you could test it on some of those coated capsules...

I have peeled pills, crushed others and opened up still others...But you must ask your pharmacist if that is advisable or not...they would be the first person to speak with and ask if there is a non-protected or non-slow-release version of your meds.

Sharon

I was advised not to use extended release meds because without a large intestine the time release is expelled before it can be fully absorbed 

I know this thread is old but I wanted to offer info to RondaC. Effexor comes in immediate release form as well. I would ask the doctor for that form.