I used it for quite awhile (close to a year?) before I switched to Immiran, because whenever I tried to wean off the entocort I would flare again. At the time entocort was not considered appropriate for long term use, although I believe they have been doing studies to look at whether long term entocort is viable. I didn’t really experience any side effects from it except for my fingernails became thin and would split/peel.