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So I had some blood work done by Cyrex labs. I had the "Intestinal Antigenic Permeability Screen" performed which tested high for my Lipopolysaccharides (LPS) IgA and IgM and equivocal for my occludin and zonulin IgA, IgG, and IgM. Apparently this means I have leaky gut syndrome indicating I have poor absorption and increased inflammation. Clearly this is not conventional medicine but, hey, aren't we all looking for answers to our problems even if not yet proven by evidence-based medicine? It was recommended to me by a naturopathic chiropractor to improve this issue by taking:

-10,000 IU of Vit D each day

-Glutathione 

-L-Glutamine powder

-Complete Digestion Enzyme

Anyone familiar with these or experienced any benefits? I believe this could get costly but if it's worth it then I'll do it. 

Thanks for any help you can provide.

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"Not yet proven" is a bit overoptimistic, but if more conventional treatments have failed you just try to maintain a reliable measure of success or failure with these other approaches. I'd suggest getting your Vitamin D measured before such an aggressive supplementation program. I take a lot of Vitamin D, but I have a science-based target for it.

Scott F

I don't generally accept any such malabsorption idea. I have about 95% of my small intestine working just fine, and a normal transit time. I think the program you're planning has as good a chance of worsening your longevity and nutritional status as improving it. The science is silent in either direction, though commerce has an opinion about where your money should be directed.

Scott F

Was that other doctor the naturopathic chiropractor, or someone else?

The way lab test abnormal values are determined in most cases makes it important that the tests be done only when there's a reason to suspect that something might be wrong. Otherwise, false positives are very common. In selected circumstances lab values provide important information even without a prior concern, but even then they don't usually stand on their own, particularly with a disease that's still murky.

Whatever "leaky gut" turns out to be, I don't think good medical practice will use it as a reason to treat people who are feeling fine.

Scott F

The article you posted is quite good. Thank you for taking the time to find an unbiased journal review, as opposed to a website trying to sell a product. What is clear is that there is yet an enormous amount of information to learn. There may well be something to this leaky gut thing, but it is more complex than you can imagine.

My point? As Scott pointed out, just because you may have food sensitivities, it does not mean you definitely have this syndrome. Also, it is not an accepted fact that we do not absorb nutrients well. If that were the case, I would not be battling obesity ever since my colectomy. I have a few deficiencies, but they resond well to specific supplementation.

Time and further research will tell!

Jan

Jan Dollar

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