Thank you, Jan. I've been taking Cipro for seven days, one tablet twice a day, 500mg. This is my second course of Cipro within six months. Last night a strange thing happened for the first time and I wonder if it has to do with Cipro or a full pouch. I had a big dinner, and usually my transit time is six hours. I always empty my bladder at the same time as my pouch. Last night and this morning I was able to slowly empty my pouch, but could not urinate no matter how long I sat. I knew my bladder was full, I had lots of water and tea. I could feel the pressure but could not urinate. There was no pain as you might have in a bladder infection. Eventually, 45 minutes later I was able to slowly empty my bladder, without pain, just slow outputting. It felt like I had a lazy bladder! Could it be my pouch was too full and pressing in my bladder? Or is Cipro playing with my system? Has anyone else experienced difficulty urinating if their pouch was full?