So I've had my pouch for 2 years now and although I have very good control over my bowel movements and holding them when I can't find a restroom, I still have taken 3 Imodium in the morning and 3 at night (I started this about 3 weeks after having my final surgery). I've never had an issue with the Imodium but this weekend I started experiencing some nausea and, over the course of 2 days, I threw up 3 times and wasn't able to hold down any food. I decided to skips my Imodium yesterday morning and felt great through out the day (besides taking frequent trips to the bathroom). Then, last night, I went ahead and took the pills right before sleeping so that I would sleep through any nausea I might have, which was successful. So, at this point, I'm thinking that day time Imodium is no longer okay for me, but I was wondering if anyone else had ever experienced this kind of issue? It seems so odd to me that it would be effecting me after almost 2 years of taking it.
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I would suspect that the Imodium is slowing your gut too much at this point. Hence the nausea. The lesson? Things change. It is not that you are suddenly reacting to the Imodium, but that your need has diminished because your gut has adapted over time to not having a colon.
Jan 
I agree - I can't take Imodium anymore - I don't do any kind of fiber..but this all happened over time with my pouch. For first several years, took fiber w/ small amount of water...then, that became something that plugged me up too much. Now, I opt for more output and lots of hydration/propel/etc. because the stopping up is not fun. Point is- your small intestines do adapt (or do for many) and change over the years - as Jan said. What works at one stage is maybe not what works at another - trial and error. Good luck tinkering with your dosage - you will get it figured out!