I used Isagenix for about a year, about three years after I had my jpouch. It was great for protein and weight loss, but like any shake supp., with a jpouch, it went right through me and I'd pass it within two hours, and it usually was a couple trips to the bathroom. I did not, however, EVER do a cleanse day. I felt like it would be too much for my pouch. I took a shot of the cleanse liquid every night instead. I al so did NOT use the magnesium, unnecessary with a pouch. I did use the metabolism accelerator supplement, which did not increase bathroom trips. I'm actually abaout to start it again!