Hi there
I am seeking some advice on what might be the cause of my difficult pouch. I have had the pouch for about 2.5 years and have never really got to a comfortable place. The main problem I have is with an unsettled pouch, mostly in the afternoons. I have periods where it is very uncomfortable and I need to go a lot over a short period of time until it eventually settles early evening. I get pain around the anus on defacation. Sometimes that is worse than others. That is sometimes it seems to be more caustic than others and I don't know why?When I am on cipro it is a lot more stable. I have tried dietry changes (fodmap) but that doesn't seem to do much. I have been scoped recently and it all looks perfectly normal, so I'm bewildered by my symptoms. I take 2 loperamide 3 times a day, metamucil twice a day, and a probiotic capsule 3 times a day.

Currently trying Pentasa to see if working on possible cuff infamation helps. If anyone has any ideas I'd love to hear them because I am stumped. Just want to live like everyone else and not have to worry about what tomorrow is going to be like. Thanks.