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Michael Hubbard
I've taken Flagyl a few times in the past for abscess' but have never taken it for pouchitis until recently. The times in the past that I've taken it I've always had the usual dizziness, headache, diarrhea, nausea etc.. so I just assumed that those would come back for this round as well. Sure enough they did.

I've been on Flagyl for about three weeks taking a pill 2x a day (instead of 3x a day for tolarance). The difference this time was that I recently got a fever, it was low grade and only for 24 hours, but now I'm not sure if I'm just dealing with Flagyl side effects or if the pouchitis is just being very persistent.

Is there anyway to tell the difference between the side effects and a bad bout of pouchitis?

Thank you

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Jan DollarJan DollarModerator, RN, retired
Since you already experienced sensitivity to Flagyl, it is not a stretch to assume your low grade fever was a drug fever. It is a fairly common phenomenon. Is the dose higher than you've taken in the past? That could be a factor, as side effects are often dose related. I would think a smaller dose three tines a day would produce less side effects than a higher dose twice a day, if the total daily dose is equivalent.

I never take more than 250mg three times a day and get excellent results with it. Only once have I needed to take it more than two weeks. But, I am aware that higher doses are needed in some cases.

Jan Smiler
Jan Dollar
Jan DollarJan DollarModerator, RN, retired
One thing I failed to mention is that if your pouchitis symptoms do not improve or worsen within a few days of starting an antibiotic, you need either a higher dose, a different antibiotic, or combination antibiotic therapy. Fever is not a typical symptom of pouchitis, but it occasionally happens. That said, if fever occurred well after starting an antibiotic, I would assume it was drug fever, unless your other pouchitis symptoms also worsened.

Jan Smiler
Jan Dollar

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