Interesting. Mike

Rhinosinusitis derived Staphylococcal enterotoxin B possibly associates with pathogenesis of ulcerative colitis.
Yang PC,
Liu T,
Wang BQ,
Zhang TY,
An ZY,
Zheng PY,
Tian DF.
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. yangp@mcmaster.ca

BACKGROUND: During clinical practice, we noticed that some patients with both ulcerative colitis (UC) and chronic rhinosinusitis (CRS) showed amelioration of UC after treatment of CRS. This study was designed to identify a possible association between CRS and UC. METHODS: Thirty-two patients with both CRS and UC received treatment with functional endoscopic sinus surgery (FESS) for CRS. Clinical symptom scores for CRS and UC, as well as serum levels of anti-Staphylococcal enterotoxin B (SEB) were evaluated at week 0 and week 12. Sinus wash fluid SEB content was measured with enzyme-linked immunosorbent assay (ELISA). The surgically removed tissues were cultured to identify growth of Staphylococcus. aureus (S. aureus). Immunohistochemistry was employed to identify anti-SEB positive cells in the colonic mucosa. Colonic biopsies were obtained and incubated with SEB. Mast cell activation in the colonic mucosa in response to incubation with SEB was observed with electron microscopy and immunoassay. RESULTS: The clinical symptom scores of CRS and UC severe scores (UCSS) were significantly reduced in the UC-CRS patients after FESS. The number of cultured S. aureus colonies from the surgically removed sinus mucosa significantly correlated with the decrease in UCSS. High levels of SEB were detected in the sinus wash fluids of the patients with UC-CRS. Histamine and tryptase release was significantly higher in the culture supernate in the patients with UC-CRS than the patients with UC-only and normal controls. Anti-SEB positive cells were located in the colonic mucosa. CONCLUSION: The pathogenesis of UC in some patients may be associated with their pre-existing CRS by a mechanism of swallowing sinusitis-derived SEB. We speculate that SEB initiates inappropriate immune reactions and inflammation in the colonic mucosa that further progresses to UC

Well, thats pretty interesting. Since I was 18 when all of a sudden I got an allergy to ragweed I've been walking around with kleenex stuffed in every pocket for my now year-round runny nose. I googled the symptoms of chronic rhinosinusitis and don't really match them (green discharge, fever, pain etc.) but nevertheless it piques my curiosity as to whether there is a link between a runny nose and UC.

That's a VERY interesting theory!

My nose runs almost contantly! It runs when I step outide, even in warmer weather, it runs when I enter a warm room, it runs when I smell perfume, it runs whenever I eat anything hot and it runs whenever I eat or drink anything cold!

I have to use Rhynocort nasal pray almost every day and in particular when I've been in a smokey/stuffy room!

I have always had this problem and I was diagnosed with UC 30 years ago (though they are now testing for Crohns) so maybe there is a connection between this and IBD?

Shell

Interesting. I am another UC / runny nose person.

When I first read the post, I thought the cure - functional endoscopic sinus surgery - sounded rather drastic. Then I realised that they are talking about the other end.

This makes me start to wonder, if we have low levels of enterotoxin in our mouth or sinus, which causes an immune problem in our gut, The elusive cause of UC, who knows. This study is from japan cant find an american one.Mike



Incidence and characterization of Staphylococcus aureus from the tongues of children.Miyake Y, Iwai T, Sugai M, Miura K, Suginaka H, Nagasaka N.
Department of Microbiology, Hiroshima University School of Dentistry, Japan.

Three hundred and seven children who had no diseases other than dental disease were examined for their oral carriage of Staphylococcus aureus, the most common persistent human pathogen. Eighty-four percent of them were positive for staphylococci, and 33% were positive for S. aureus. Among the 100 strains of S. aureus isolated, 40 strains produced enterotoxin, and 19 strains produced exfoliative toxin. Their susceptibility to antibiotics was also investigated: Six strains demonstrated resistance to methicillin (MIC greater than or equal to 12.5 microgram/mL), and 50% of the isolates were borderline resistant (MIC of 3.13 to 6.25 micrograms/mL) to the drug. These data suggest that the mouths of children could be reservoirs of
S. aureus.

2 years ago I had major sinus surgery, like 4 procedures at once. I'd tell you what they were, but I can't pronounce a single one of them.