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grapefruit and drugs
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Picture of kathy smith
posted
The NY Times posted an article on the interaction between drugs and grapefruit. There are now 85 drugs on the market whose potency is dramatically increased if taken with grapefruit, including common cholesterol-lowering drugs, new anti-cancer agents, and some synthetic opiates and psychiatric drugs, as well as certain immunosuppressant medications taken by organ transplant patients, some AIDS medications, and some birth control pills and estrogen treatments.

There is a link to the complete list in the article.

However, just an anecdotal addendum - my goddess mother has been eating fresh grapefruit every morning for 6 or 7 decades. She's 90 years old, still works fulltime, does all her own shopping/cooking/cleaning, has an amazing memory about just about everything ever, and has more energy than a person a third her age. So this information is provided just for awareness' sake.

(Oh, and she has a scotch and bubbly water cocktail or two every single night. Maybe it's the combination of grapefruit and scotch that does the trick.)

kathy Big Grin


***********************************************************
Lately it occurs to me, what a long strange trip it's been..... Grateful Dead
 
Posts: 9461 | Location: california | Registered: June 30, 2000Report This Post
Picture of CTBarrister
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There is a warning on my Entocort prescription label not to eat grapefruit with that medication, and I have given up grapefruit since going on Entocort (aka Budesonide).

This message has been edited. Last edited by: CTBarrister,


CTBarrister
UC - 1972 as a 9 year old
Takedown 1992
Chronic Pouchitis Onset 1995
Still J Pouching 2014
 
Posts: 3191 | Location: Connecticut, USA | Registered: April 12, 2007Report This Post
Picture of kathy smith
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I know that there have been warnings about grapefruit/drug reactions for quite awhile. What I thought was interesting about this article was that it lists the drugs, predicted interaction risk rank, and what the adverse reaction might be. For instance, who would ever think that taking a cardiovascular medication with grapefruit could cause gangrene?

When I was young, there was a warning 'out there' that cranberries caused cancer. That was the entire statement. My cousin, who was/is a medical researcher said that that was true. Shock! But one would have to eat a boxcar load of cranberries every day to get cancer. She said that a boxcar load of just about anything could 'cause' cancer. That's something that's always stuck in some part of my brain - that there are extenuating circumstances and we should be aware of the risks and then make choices.

There are a couple of my drugs on the list and it's great to know what to look for. I eat grapefruit occasionally and probably won't stop because it's so infrequent. But then again, I'd have only me to blame if I 'got' gangrene.

kathy Big Grin


***********************************************************
Lately it occurs to me, what a long strange trip it's been..... Grateful Dead
 
Posts: 9461 | Location: california | Registered: June 30, 2000Report This Post
Picture of skn69
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Kathy,

Thanks for the article. There is an automatic verification here whenever we pick up our scripts...my anticonvulsive is on that list...apparently grapefruit makes it More effective and not less...a lot of drugs' reactions are increased with the consumption of grapefruit and not the contrary as I had expected...they are also talking about all citrus fruits now...orange, tangerine, lemon etc...so juice & coffee plus your meds might just become a thing of the past...
Sharon


It could be worse...oh, wait..it already has been! then I guess it can only get better from here....
 
Posts: 4854 | Location: Paris, France | Registered: July 29, 2007Report This Post
Picture of Scott F
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Most commonly grapefruit changes the blood levels of the interacting drug, and only if they're taken more or less together. So you don't have to swear off grapefruit, just not eat it at the same time as the interacting medicine. The same applies to dairy products and Cipro.

I'd caution against using the term "more effective" to describe an increased blood level. It's more like an overdose.


--Scott

Crohn's Dx 1980
Single-stage J-pouch 2002 - Dx changed to Indeterminate IBD
 
Posts: 1229 | Location: Towson, MD | Registered: December 10, 2012Report This Post
Picture of CTBarrister
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Scott,

I pretty much understood that to be the case, but I am under orders to take my Entocort in the morning, and the only time I would be eating grapefruit in the 1st place would be in the morning at breakfast. To be honest, it is not that big a deal for me to give up grapefruit because it is not really my favorite fruit anyway.


CTBarrister
UC - 1972 as a 9 year old
Takedown 1992
Chronic Pouchitis Onset 1995
Still J Pouching 2014
 
Posts: 3191 | Location: Connecticut, USA | Registered: April 12, 2007Report This Post
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For me, grapefruit was a take it or leave it fruit until I was not allowed to eat it because of the statin I was taking for cholesterol control. Then, grapefruit became an obsession! I could taste it in my sleep.....almost! Finally, I broke down and had grapefruit three days in a row. That was months ago. And so far.....I haven't had the craving!


C.E.M.
 
Posts: 734 | Location: Southern California | Registered: February 06, 2011Report This Post
Picture of skn69
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As Scott said, as long as you do not take them simultaneously then there is no problem...I used to eat a grapefruit every morning (sometimes 2) but I was told not to because I take my meds then so I eat them a 4pm for snack...ditto for evenings...I take the anticonvulsives 2xs day...by the way the expression 'more effective' is the direct translation from the French...'Plus Efficace'...my doctor also told me that I shouldn't worry too much because the effect was not dangerous in my case and that I should adjust the dose accordingly if I insisted on eating them...(lower the dosage)...but there is now a T.V. campaigne to eat your grapefruits in the evenings...keep the info coming...
Sharon


It could be worse...oh, wait..it already has been! then I guess it can only get better from here....
 
Posts: 4854 | Location: Paris, France | Registered: July 29, 2007Report This Post
Picture of Jan Dollar
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Unfortunately, it actually is not true that this interaction only occurs when the juice is consumed at the same time as the drug. The effect of blocking the enzyme can last for more than a day. But, the effect is not the same universally, so itdepends on the drug, the dose, and the amount of grapefruit consumed. So, something to be worked out with your pharmacist or doctor. If you have grapefruit daily, perhaps you can get by with a lower dose.

http://www.medicinenet.com/scr...asp?articlekey=14760

Jan Smiler


Take a deep breath and relax; this too will pass.
 
Posts: 22809 | Location: Fremont, CA, USA | Registered: April 07, 2000Report This Post
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Grapefruit? Blech! Wink
 
Posts: 82 | Location: California | Registered: October 09, 2012Report This Post
Picture of Scott F
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I stand corrected. Thanks for catching that, Jan.


--Scott

Crohn's Dx 1980
Single-stage J-pouch 2002 - Dx changed to Indeterminate IBD
 
Posts: 1229 | Location: Towson, MD | Registered: December 10, 2012Report This Post
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